Master Theses and Semester Projects

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Current Projects

Positions are available only for FS2018, summer of 2018 (8 weeks, only semester project) or HS2018.

Synthesis of Photoactivatable Dyes for Detecting Cells in the Lymphatic System

The aim of the project is to develop functionalized, photoactivatable dyes for detecting migration of sub-dermal cells to the lymphatic system. This project is done in collaboration with the Pharmaceutical Immunology Laboratory of ETH (Prof. C. Halin-Winter). The project will involve the following research tasks:

- Synthesis of the dyes: Reaction set-up, purification methods and structural characterization (MS, NMR, etc.)
- Optical spectroscopy: Electronic absorption (UV/Vis) and fluorimetry.
- Mammalian cell culture.
- Fluorescence microscopy employing live cells and a confocal (spinning-disk) microscope.
- Together with the Halin-Winter lab, implementation of the probes in live animals.

For more information about the project contact Mr. Elias Halabi (). To apply, please contact Prof. Pablo Rivera-Fuentes () and include a copy of your Leistungsüberblick obtained from “myStudies”.

PAR
Single cell activation of mammalian HeLa cell with photoactivatable rhodamine dye. Scale bar - 10 um
PAG2
Point activation of a section of a mammalian HeLa cell with photoactivatable rhodamine dye. Scale bar - 10 um

Development of an Endoplasmic Reticulum Targeting Vector

The aim of the project is to develop a membrane-permeable peptidomimetic vector which will target the endoplasmic reticulum (ER). The peptide will incorporate a fluorophore for determining the ability of the vector to pass the cellular membrane and accumulate into the ER.

The project will involve the following research tasks:

  • Synthesis of the fluorophore and peptidomimetic vector:  Reaction set-up, solid-phase synthesis, purification methods and structural characterization (MS, NMR, etc.)
  • Optical spectroscopy: Electronic absorption (UV/Vis) and fluorimetry.
  • Mammalian cell culture
  • Fluorescence microscopy employing live cells and a confocal (spinning-disk) microscope.

For more information about the project contact Ms. Alina Tirla (). To apply, please contact Prof. Pablo Rivera-Fuentes () and include a copy of your Leistungsüberblick obtained from “myStudies”.

PAg3
Endoplasmic reticulum (ER) of a human cancer cell tagged with a genetically-encoded fluorescent marker (green fluorescent protein, GFP)
 
 
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Wed Jun 28 13:07:29 CEST 2017
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